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Beyond the Primary Endpoint: Cardiometabolic and Body-Composition Signals Both compounds act on a hormonal axis with wide-ranging metabolic effects, so it is reasonable to ask what happens beyond the headline endpoint

"People are taking GLP-1 drugs -- like Wegovy and Zepbound -- for weight loss now more than ever," Defense Health Agency Chief Medical Officer Dr

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These efficacy differences matter when selecting therapy: patients who need maximal weight loss or have struggled to reach glycemic goals on other agents may benefit most from higher efficacy options